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Work package 3.Validation of protective effect of dairy functional foods against metals induced toxicity in animals A 3.1. Heavy metal-induced toxicity and nanoselenium enriched probiotics – experimental design
A 3.2. Evaluation of protective effects of nanoselenium enriched probiotics by biochemical analysis
A 3.3. Evaluation of protective effects of nanoselenium enriched probiotics by histopathology analysis
Aspectul histologic al ficatului la loturile experimentale
A 3.4. Evaluation of anti-inflammatory and anti-fibrotic effects of nanoselenium enriched probiotics by imunohistochemical and qene expression studies by qPCR of specific involved citokines and related genes
Expresia imunohistochimică hepatică a TNFα.1
Expresia genică a TNF-αla nivel hepatic
A 3.5. Evaluation of protective effects of nanoselenium enriched probiotics by electronmicroscopy analysis
Aspectul ultrastructural al celulelor epiteliale tubular renale 1- control; 2- CdCl2;3- CdCl2+0.4 mg/kg LactoNanoSe
A 3.6. Global epigenetic alterations in tissues induced by Cd and evaluation of protective effects of nanoselenium enriched probiotics
Analiza prin electroforeză a produșilor de amplificare pentru gena TNFα: 1,2 – Control; 3,4 – Cadmiu ; 5,6 - Cadmiu + NanoSe 0.1; 7, 8 - Cadmiu + NanoSe 0.2; 9, 10 - Cadmiu + NanoSe 0.4; 11, 12 - Cadmiu + LactoSe 0.1; 13, 14 - Cadmiu + LactoSe 0.2; 15, 16 - Cadmiu + LactoSe 0.4.
A.3.7. Determination of total antioxidant capacity of plasma
Capacitatea antioxidanta a plasmei determinata prin metoda FRAP
A3.8. Assessment of antioxidant status and peroxidative stress from different tissues
Activitatea catalazei din ficat
A 3.9. Dissemination of project results
Rezultatele obținute în cadrul proiectului au fost valorificate prin publicarea datelor într-o revistă ISI și o revista BDI, și participarea la 2 Congrese:
· Cavalu S., Antoniac I.V., Fritea L., Mates IM., Milea C., Laslo V., Vicas S., Mohan A. Surface modifications of the titanium mesh for cranioplasty using selenium nanoparticles coating . Journal of Adhesion Science and Technology (TAST). Article ID: TAST 1490067. DOI: 10.1080/01694243.2018.1490067-accepted on Jun 09, 2018 (IF:1.073) · Tocai M., Cavalu S., Laslo V., Burescu P., Vicas S. 2018. Antioxidant capacity and total phenols content changes of broccoli sprouts after exogenous supply with nano selenium. International Journal of Current Research 10 (3),66592-66594 · Laslo V., Cavalu S., Vicas S. 2018. The green synthesis of metallic nanoparticles (silver and selenium) using plant extracts. International Symposium Research and Education in an Innovation Era-7th Edition. Arad May 17-20 · Balta C., Herman Hildegard, Rosu M, Gharbia S, Prokisch J, Vicas S, Hermenean A. Hepato-and nephroprotective effects of biologically synthesized selenium nanoparticles on cadmium-induced toxicity in mice. The 36th Annual Scientific Session of the Romanian Society for Cell Biology. The 10th National Congress with International Participation. P. 23. 6-9 Iunie,Craiova 2018.
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